Référence:Respiratory alkalosis may impair the production of vitamin D and lead to significant morbidity, including the fibromyalgia syndrome

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En quelques mots
Concerne les maladies : Syndrome fibromyalgique, Mal aigu des montagnes
Étudie les aspects: Cause, Symptôme
A pour fiabilité: Nouvelles données scientifiques
A pour public cible: Chercheurs
Langue: Anglais
Pays: USA
Étudie les causes: Hyperventilation, Stress
Étudie les symptômes: Vitamine D, Syndrome fibromyalgique, Mal aigu des montagnes
Étudie les outils de diagnostic: Vitamine D
Étudie les traitements:
Mention spéciale pour:

Auteurs: John M. Lewis, Toinette H. Fontrier, J. Lynn Coley

Publié en: 2017

Lien vers l'article original: https://www.medical-hypotheses.com/article/S0306-9877(16)30210-9/fulltext

Résumé en Français:[modifier le wikicode]

L'hyperventilation causée par le stress peut perturber la production de Vitamine D et pourrait causer des syndromes fibromyalgiques.

Abstract en langue originale:[modifier le wikicode]

Hyperventilation caused by physical and/or psychological stress may lead to significant respiratory alkalosis and an elevated systemic pH. The alkalotic pH may in turn suppress the normal renal release of phosphate into the urine, thereby interrupting the endogenous production of 1,25-dihydroxyvitamin D (calcitriol). This could cause a shortfall in its normal production, leading to a variety of adverse consequences. It might partially explain the pathogenesis of acute mountain sickness, a treatable disease characterized by severe hyperventilation secondary to the hypoxia of high altitude exposure. Milder degrees of hyperventilation due to different forms of stress may produce other conditions which share characteristics with acute mountain sickness. One of these may be the fibromyalgia syndrome, a chronic painful disorder for which no satisfactory treatment exists. Should fibromyalgia and acute mountain sickness have a common etiology, may they also share a common form of treatment? Evidence is presented to support this hypothesis.