Référence:Co-infection of Ticks: The Rule Rather Than the Exception
|En quelques mots|
|Concerne les maladies :||Babésiose, Maladie de Lyme, Rickettsiose, Maladie des griffes du chat, Anaplasmose humaine, Bartonellose|
|Étudie les aspects:||Cause, Prévalence|
|A pour fiabilité:||Nouvelles données scientifiques|
|A pour public cible:||Chercheurs, Médecins, Patients, Institutions|
|Étudie les causes:||Tiques, Babesia, Borrelia, Rickettsia, Bartonella, Anaplasma phagocytophilum|
|Étudie les symptômes:|
|Étudie les outils de diagnostic:||RT-PCR|
|Étudie les traitements:|
|Mention spéciale pour:||Alerte|
Auteurs: Sara Moutailler, Claire Valiente Moro, Elise Vaumourin, Lorraine Michelet, Florence Hélène Tran, Elodie Devillers, Jean-François Cosson, Patrick Gasqui, Van Tran Van, Patrick Mavingui, Gwenaël Vourc’h, Muriel Vayssier-Taussat
Publié en: 2016
Lien vers l'article original: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795628/
Résumé en Français:[modifier le wikicode]
Une étude portant sur les tiques mettant en avant les taux importants de co-infections dans les Ardennes françaises. 45% des tiques étaient infectés et la moitié d'entre eux co-infectés. Ces taux sont plus élevés que ceux relevés aux Etats Unis dans les régions endémiques.
Abstract en langue originale:[modifier le wikicode]
Introduction Ticks are the most common arthropod vectors of both human and animal diseases in Europe, and the Ixodes ricinus tick species is able to transmit a large number of bacteria, viruses and parasites. Ticks may also be co-infected with several pathogens, with a subsequent high likelihood of co-transmission to humans or animals. However few data exist regarding co-infection prevalences, and these studies only focus on certain well-known pathogens. In addition to pathogens, ticks also carry symbionts that may play important roles in tick biology, and could interfere with pathogen maintenance and transmission. In this study we evaluated the prevalence of 38 pathogens and four symbionts and their co-infection levels as well as possible interactions between pathogens, or between pathogens and symbionts.
Methodology/principal findings A total of 267 Ixodes ricinus female specimens were collected in the French Ardennes and analyzed by high-throughput real-time PCR for the presence of 37 pathogens (bacteria and parasites), by rRT-PCR to detect the presence of Tick-Borne encephalitis virus (TBEV) and by nested PCR to detect four symbionts. Possible multipartite interactions between pathogens, or between pathogens and symbionts were statistically evaluated. Among the infected ticks, 45% were co-infected, and carried up to five different pathogens. When adding symbiont prevalences, all ticks were infected by at least one microorganism, and up to eight microorganisms were identified in the same tick. When considering possible interactions between pathogens, the results suggested a strong association between Borrelia garinii and B. afzelii, whereas there were no significant interactions between symbionts and pathogens.
Conclusion/significance Our study reveals high pathogen co-infection rates in ticks, raising questions about possible co-transmission of these agents to humans or animals, and their consequences to human and animal health. We also demonstrated high prevalence rates of symbionts co-existing with pathogens, opening new avenues of enquiry regarding their effects on pathogen transmission and vector competence.