Référence:Babesiosis Treatment & Management
|En quelques mots|
|Concerne les maladies :||Babésiose|
|Étudie les aspects:||Synthèse|
|A pour fiabilité:||Consensus scientifique|
|A pour public cible:||Médecins, Patients, Institutions|
|Étudie les causes:||Babesia, Babésia Microti|
|Étudie les symptômes:|
|Étudie les outils de diagnostic:||QPCR, RT-PCR, PCR, Sérologie, Frottis sanguin, Numération formule sanguine, Biochimie du sang, Inoculation à l'animal, Analyse d'urine, Radiographie des poumons|
|Étudie les traitements:||Clindamycin, quinine, atovaquone, azithromycin, proguanil, malarone|
|Mention spéciale pour:||Synthèse|
Auteurs: Burke A Cunha, Michael Stuart Bronze, Edward Bessman, Itzhak Brook, Vinod K Dhawan, Allan D Friedman, Tarlan Hedayati, Rick Kulkarni, Cameron Nima Nourani, Om Prakash Sharma, Sat Sharma, Barry J Sheridan, Russell W Steele, Francisco Talavera, Martin Weisse, Mary L Windle
Publié en: 2017
Lien vers l'article original: https://emedicine.medscape.com/article/212605-overview
Résumé en Français:[modifier le wikicode]
Une synthèse américaine assez complète qui reste lisible. Très détaillée sur les tests.
Abstract en langue originale:[modifier le wikicode]
Babesiosis is a tick-borne malaria-like illness caused by species of the intraerythrocytic protozoan Babesia. Humans are opportunistic hosts for Babesia when bitten by nymph or adult ticks. Currently, Babesia infection is transmitted by various tick vectors in Europe, Asia, and the northwestern and northeastern United States.
Human babesiosis is a zoonotic infection in which ticks transmit Babesia organisms from a vertebrate reservoir to humans [1, 2] ; the infection is incidental in humans. The primary Babesia species that infect cattle include Babesia divergens, Babesia bigemina, Babesia bovis, and Babesia major. In horses, the main species is Babesia equi. Babesia canis is the primary species in dogs, and Babesia felis is the main species in cats. Babesia microti is the species found in mice.
Babesia species and organisms of the closely related genus Theileria have worldwide distribution, parasitizing the erythrocytes of wild and domestic animals. These parasites are commonly called piroplasms because of the pear-shaped forms found within infected red blood cells (RBCs). Most human babesial infections are caused by B microti (found only in the United States) or by B divergens and B bovis (found only in Europe).
Human babesiosis is infrequent and occurs in limited geographic locations. In the United States, it is usually an asymptomatic infection in healthy individuals. Several groups of patients become symptomatic, and, within these subpopulations, significant morbidity and mortality occur. The disease most severely affects patients who are elderly, immunocompromised, or asplenic.
Babesiosis is difficult to diagnose. Although the index of suspicion should be high in areas endemic for Babesia infection, patients with babesiosis have few, if any, localizing signs to suggest the disease. Confirmation of the diagnosis depends on the degree of parasitemia and the expertise and experience of the laboratory personnel.
Most patients infected by B microti who are otherwise healthy appear to have a mild illness and typically recover without specific chemotherapy; however, treatment is recommended for all diagnosed cases to prevent sequelae and potential transmission through blood donation. In addition, patients should be advised to take precautions against tick exposure and to refrain from donating blood until completely cured of babesiosis.